Misao Kusakabe is a childhood friend of Ayano since middle school, along with Kagami, her fellow classmate.

Misao tends to be quite lazy, simple-minded and an outdoor type of person. She is in the track and field club, hates studying, and harbors a love for video games, despite not being particularly talented at them. She has tanned skin, dark hair slightly slanted eyes, and a small fang in the side of her mouth. (Very moe if I say so myself)

Misao does not seem to be skilled at playing video games, yet plays them for purely for fun; she notes on having borrowed many games from various people. In fact, her concept of "play for fun" is so strong that she does not mind losing to Kagami, instead marveling at how well her friend plays and making a loud, congratulatory spectacle.

This leaves Kagami with a sense of guilt and bewilderment. At one point, Kagami compared Ayano and Misao to Tsukasa and Konata respectively, saying that she apparently tends to attract the same kinds of friends.

Misao dislikes Konata for "stealing" Kagami away from her group, and often rants about Kagami leaving her group for Konata who she knew for only one to two years. She calls Konata by the name "Chibikko" which is literally used as an equivalent for "midget" or "Little Girl" and can be literally translated to "a very tiny child", and she is nicknamed "Misakichi" by Konata in the Manga.